All diagrams in overview and genetic evidence
Development synapse formation and maintenance
Developmental biology and genetic association require different evidence. Rare-gene examples belong to the rare-variant source, not the 2023 GWAS.
Development synapse formation and maintenance
Evidence interpretation
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Neuronal differentiation, synapse formation and maintenance provide a biological context for investigating genetic associations. The figure does not assign each named gene to one mandatory developmental stage. MAP1A, ANK2 and ANO8 are examples from the rare-variant paper published online in 2025 and in the 2026 issue; they must not be attributed to the 2023 common-variant GWAS. An association or enrichment can motivate experiments but does not demonstrate an individual developmental lesion.
What the diagram shows
Neuronal differentiation, synapse formation and maintenance provide a biological context for investigating genetic associations. The figure does not assign each named gene to one mandatory developmental stage. MAP1A, ANK2 and ANO8 are examples from the rare-variant paper published online in 2025 and in the 2026 issue; they must not be attributed to the 2023 common-variant GWAS. An association or enrichment can motivate experiments but does not demonstrate an individual developmental lesion.