All diagrams in medicine handling and targets
Medication absorption metabolism and elimination
Drug exposure is not the same thing as synaptic transmitter metabolism. These steps do not supply a dose or justify changing a prescribed regimen.
Medication absorption metabolism and elimination
Scoped educational mechanism
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Read the diagram explanation and sources
Absorption, distribution, metabolism and elimination describe pharmacokinetics. They differ between medicines and formulations. For dexamfetamine, the current UK product information describes gastrointestinal absorption, distribution including brain entry, biotransformation and urinary elimination. This general diagram does not specify a concentration, dose or metabolic genotype interpretation. Clinical effect and tolerability require assessment and monitoring; systemic drug handling must not be conflated with MAO/COMT handling of dopamine.
- Medicine and formulation → Absorption: entry
- Absorption → Distribution: circulation
- Distribution → Biotransformation: metabolism
- Biotransformation → Elimination: clearance
What the diagram shows
Absorption, distribution, metabolism and elimination describe pharmacokinetics. They differ between medicines and formulations. For dexamfetamine, the current UK product information describes gastrointestinal absorption, distribution including brain entry, biotransformation and urinary elimination. This general diagram does not specify a concentration, dose or metabolic genotype interpretation. Clinical effect and tolerability require assessment and monitoring; systemic drug handling must not be conflated with MAO/COMT handling of dopamine.