All diagrams in synapses and receptor signalling
PFC receptor signalling in a defined context
A specific experimental context: prefrontal working-memory circuits. More stimulation does not mean more benefit in every context.
PFC receptor signalling in a defined context
Scoped educational mechanism
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Primate prefrontal experiments support alpha2A-associated regulation of cAMP/HCN signalling and recurrent activity, and non-linear D1 effects on neurons engaged in working memory. These are defined cellular/task contexts. A conceptual inverted-U result is not a measured curve for an individual, a plasma-level target, a universal effect across brain regions or a justification for increasing medication. The figure deliberately avoids numerical concentrations and dose recommendations.
- Alpha2A receptor → cAMP / HCN modulation: signalling
- cAMP / HCN modulation → Network connection: modulation
- D1 receptor → Working-memory tuning: modulation
What the diagram shows
Primate prefrontal experiments support alpha2A-associated regulation of cAMP/HCN signalling and recurrent activity, and non-linear D1 effects on neurons engaged in working memory. These are defined cellular/task contexts. A conceptual inverted-U result is not a measured curve for an individual, a plasma-level target, a universal effect across brain regions or a justification for increasing medication. The figure deliberately avoids numerical concentrations and dose recommendations.