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Section overview
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Find useful resources
Interruptions in ADHD treatment
ADHD & daily life
Section overview
Starting a task
When understanding is not enough
Relatable examples
Understand your experience
Memory, time & awareness
Pain, fatigue and movement
Fatigue, sleepiness and sleep disruption
Brain & genetics
Section overview
What ADHD is
Genetics library
Section overview
Genetics and ADHD: start here
ADHD and genes: what the evidence shows
How to read a genetic claim
The dopamine supply chain in plain English
Common variants, rare variants and the heritability gap
Polygenic scores: what they can and cannot do
When movement symptoms and ADHD traits overlap: single-gene conditions clinicians consider
Family history and inheritance patterns
Autism genetics in brief
Genetics glossary
The 27 ADHD risk loci: a closer look
Mechanisms & evidence
Section overview
Explore evidence
ADHD and biology — the overview
Genetics — many small influences
Brain development and structure
The dopamine and noradrenaline supply chain
No single dopamine story
Open research questions
The dopamine pathway explorer
Process atlas
Section overview
Atlas overview
Overview and genetic evidence
Section overview
Whole system overview
Genes regulation and development
Large scale brain networks
Cognitive functions and observable outcomes
Development synapse formation and maintenance
Contextual genetic overlay
Common locus to effector gene evidence
Supply, synthesis and cofactors
Section overview
Amino acid supply and brain entry
Catecholamine synthesis and cell type branches
BH4 synthesis and cofactor recycling
Vitamin and mineral support
Serotonin supply and transmission
One carbon metabolism and methyl donors
TH reaction and regulation
DBH and PNMT compartment detail
BH4 hydroxylase recycling and salvage
Synapses and receptor signalling
Section overview
Vesicle loading and storage
Release and vesicle recycling
Synaptic clearance and intracellular metabolism
Receptors and intracellular response
Glutamate transmission
GABA transmission and inhibition
Acetylcholine and attention modulation
Astrocytes and transmitter recycling
DAT uptake and ion gradients
PFC receptor signalling in a defined context
Glutamate glutamine cellular shuttle
Energy and cellular support
Section overview
Energy supply and neuronal demand
Redox balance and glutathione
Mitochondrial quality control: one mitophagy route
Immune signalling and neural context
Blood flow oxygen and glucose delivery
Mitochondrial membrane and respiratory chain
Context and arousal
Section overview
Dopamine and noradrenaline projection systems
Sleep circadian timing and arousal
Adrenal hormones: two tissue compartments
Nutrition: supply, transport and evidence limits
Histamine and orexin arousal modules
Medicine handling and targets
Section overview
Medication absorption metabolism and elimination
Medication target overlays
Amphetamine dexamfetamine at the dopamine terminal
Neurological symptoms
Section overview
A field guide to the nervous system
Movement, pain & sensation
Section overview
Dystonia: patterned twisting and spasms
Stiffness, spasms and spasticity
Coordination and balance: understanding ataxia
Burning, electric and touch-sensitive pain
Strong sensation, unclear position feedback
Condition guides
Section overview
Hereditary spastic paraplegia: what assessment looks for
Dopamine-responsive dystonia: a distinct clinical question
Parkinson’s: symptoms, treatment, genetics and care
FND: diagnosis, active treatment and accountable care
Medication & treatment
Section overview
Medications & Supplements
Understand treatment
How ADHD medicines act
What treatment trials show
Formulations & response
Restarting after a gap
Dopamine-related treatments: different jobs
Saffron and Mucuna: what the evidence actually says
Medical cannabis in depth
Strain & chemovar reviews
Getting care
Section overview
Navigate care
No current prescriber
When treatment stops
Transfers & Right to Choose
Records and escalation
Prepare for an appointment
When help doesn't come: get it in writing
Rights & accountability
Section overview
Access and adjustments
UK mental health care accountability
People harmed: the case register
Matthew Leahy: testimony and response
Cases & responsibilities
Section overview
Lives and accountability
Matthew's timeline
My case: who owned the next decision?
Who is responsible?
Rules, rights and safeguards
When findings do not become improvements
Lives remembered
Matthew Leahy: testimony and response
Media framing and evidence
My treatment journey
Interruptions in ADHD treatment
Evidence & resources
Section overview
Source documents
Evidence map
How evidence is handled
Verified numbers
Living archive
Source register
How evidence is labelled
Corrections log
About MJB
Method and tools
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